Denis Vivien

This study identifies cerebral microthrombi as focal sites of Cav-1-dependent BBB dysfunction after TBI, linking microvascular thrombosis to neuronal damage through transcytosis.

This study compares postnatal maturation of the gliovascular unit in male and female mice, revealing sex-specific differences in angiogenesis, cell composition, and transcriptomic trajectories regulated by oestrogenic signalling.

This study develops a dual-action nanoconjugate combining r-tPA and DNase to target r-tPA-resistant clots, showing improved reperfusion and reduced lesion volume in an ischemic stroke model.

This study shows that endothelial tPA helps microglia protect the blood-brain barrier after stroke in mice by reducing vascular inflammation and maintaining BBB integrity.

This study shows that endothelial NMDA receptors are critical for retinal vascular development and mediate prenatal alcohol exposure-induced neurovascular defects in mice.

This study profiles systemic immune changes in a murine OA model, finding reduced MHCII on macrophages and DCs, increased tolerogenic DCs, and shifts in T cell composition.

This paper develops a bimodal imaging probe for monitoring systemic inflammation using immuno-PET and immuno-MRI, demonstrating its efficacy in a murine model of rhabdomyolysis.

This study examines how resting-state functional connectivity and sleep spindle dynamics influence memory consolidation in older adults, finding that reduced brain network specialization is linked to poorer memory consolidation.

This paper demonstrates 3D ultrasound localization microscopy can image major sheep brain vessels, mimicking human skull conditions, but with limited field-of-view.

This study shows that mTORC1 inhibition with rapamycin reduces brain damage and neuronal loss after ischemia by modulating microglial reactivity.

This study shows that leptomeningeal collaterals regulate reperfusion in ischemic stroke, with poor collaterals leading to hemorrhage and poor outcomes.

This study shows that MLC1 is essential for postnatal development of the gliovascular unit, leading to vascular and fluid clearance defects in a mouse model of megalencephalic leukoencephalopathy.

This study shows that environmental enrichment reduces relapse incidence and severity in experimental autoimmune encephalomyelitis, counteracting the effects of repeated acute stress.