Author

Cindy X. Chen

University of California, IrvineORCID 0000-0002-0455-9931Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Ethan W. HollingsworthiD· 2 shared Evgeny Z. KvoniD· 2 shared Sandra H. JacintoiD· 2 shared Taryn Audrey LiuiD· 2 shared Joshua A. AlcantaraiD· 1 shared Zhuoxin CheniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 14 mutual co-author links

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2 shared papersGenomics

Ethan W. HollingsworthORCID

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2 papers

Recent·Most cited

Enhancer Poising Enables Pathogenic Gene Activation by Noncoding Variants

Ethan W. Hollingsworth, Zhuoxin Chen, Cindy X. Chen, Sandra H. Jacinto, Taryn Audrey Liu, Evgeny Z. Kvon

The paper shows that poised enhancers are susceptible to non-coding variants causing gene activation and disease, using the ZRS and autism-associated variants as examples.

bioRxiv · Jun 20, 2025 · PreprintGenomics

Rapid and Quantitative Functional Interrogation of Human Enhancer Variant Activity in Live Mice

Ethan W. Hollingsworth, Taryn Audrey Liu, Joshua A. Alcantara, Cindy X. Chen, Sandra H. Jacinto, Evgeny Z. Kvon

This paper introduces dual-enSERT, a tool for rapidly measuring enhancer variant activity in live mice, and shows it can identify shared genetic mechanisms in non-coding variant pathogenesis.

Nature Communications · Jan 6, 2025Peer-reviewedGenomics