Zhuoxin Chen

The paper identifies a conserved enhancer cluster regulating efnb2 expression in the dorsal retina and links it to human retinal thickness variation.

The paper shows that poised enhancers are susceptible to non-coding variants causing gene activation and disease, using the ZRS and autism-associated variants as examples.

The paper examines 3D enhancer-promoter interactions during mammalian development, finding that most enhancers bypass neighboring genes and show tissue-specific conformations with increased interactions upon activation.

This study uses scLOESS to trace lineage commitments in zebrafish embryos, revealing development histories and ongoing lineage events through single-cell analysis.