Machine learning modeling of protein-intrinsic features predicts tractability of targeted protein degradation
Wubing Zhang, Shourya S. Roy Burman, Jiaye Chen, Katherine A. Donovan, Yang Cao, Chelsea Shu, Boning Zhang, Zexian Zeng, Shengqing Stan Gu, Yi Zhang, Dian Li, Eric S. Fischer, Collin J. Tokheim, X. Shirley Liu
The paper develops a machine learning model to predict protein degradability for targeted protein degradation, identifying key features and extending predictions to the proteome.
Genomics Proteomics & Bioinformatics · Oct 1, 2022Peer-reviewedBioinformatics