Shengqing Stan Gu

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

This study examines how allogeneic stem cell transplant affects subclonal evolution in chronic lymphocytic leukemia, identifying cellular homogeneity as a biomarker for immune response.

This study investigates the evolutionary timing of immune escape mutations across 38 cancer types using functional genomics and tumor evolution reconstruction.

MetaTiME identifies data-driven meta-components in tumor immune microenvironment scRNA-seq data to annotate cell states and reveal transcriptional regulators.

The paper develops a machine learning model to predict protein degradability for targeted protein degradation, identifying key features and extending predictions to the proteome.

This study shows MYC overexpression disrupts AR transcriptional pause release, promoting aggressive prostate cancer progression.

CoBRA provides a reproducible pipeline for ChIP/ATAC-seq analysis, including peak calling, clustering, and pathway analysis, with code available at the given URL.