Jiaye Chen

Spatial Total RNA Sequencing of Formalin-Fixed Paraffin Embedded Tissues by spRandom-seq

This paper introduces spRandom-seq, a spatial RNA sequencing method for FFPE tissues, which captures both host and microbial RNAs with higher efficiency than oligo(dT)-based methods.

Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer's Disease fly models

The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.

Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution

The paper presents an aging Drosophila cell atlas, identifies cell type-specific aging patterns, and shows ribosomal gene expression as a conserved aging predictor.

Machine learning modeling of protein-intrinsic features predicts tractability of targeted protein degradation

The paper develops a machine learning model to predict protein degradability for targeted protein degradation, identifying key features and extending predictions to the proteome.

Full-length isoform transcriptome of developing human brain provides new insights into autism

The paper analyzes full-length splicing isoforms in the developing human brain to identify isoform-level changes associated with neurodevelopmental disorders and highlights the importance of studying mutations at the isoform level.

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

This study shows that Cul3 haploinsufficiency in mice causes social and cognitive deficits, cortical volume reduction, and cytoskeletal defects, which are rescued by RhoA inhibition.