PathologybioRxivPreprint
Arterial endothelial deletion of hereditary hemorrhagic telangiectasia 2/Alk1 causes epistaxis and cerebral microhemorrhage with aberrant arteries and defective smooth muscle coverage
Xuetao Zhang, Kyle A. Jacobs, Kunal P. Raygor…·Rong A. Wang
This study shows that somatic Alk1 mutation in arterial endothelial cells causes epistaxis and cerebral microhemorrhage in mice, suggesting a mechanism for HHT-associated bleeding.
DOI 10.1101/2024.11.25.622742