Kyle A. Jacobs

This study shows that perivascular matrix densification promotes fibrosis by activating pro-inflammatory endothelial cells through a novel VE-cadherin-TGF-βR2 axis.

This study identifies FAM83H as a regulator linking keratin organization to Notch signaling in epidermal morphogenesis, showing its role in keratinocyte differentiation and cell-cell adhesion.

This study identifies JCAD as a scaffold that links tight junction condensates to actin and RhoA, enabling endothelial barrier adaptation to inflammation.

StrataChip enables dynamic study of human epidermal morphogenesis by integrating microfluidics with single-cell RNA-sequencing and imaging, revealing transcriptional and mechanical transitions during stratification.

The paper identifies Scrib's role in organizing cortical actomyosin clusters to stabilize adherens junctions and support angiogenic sprouting.

The paper identifies a flow-specific Notch1 mechanotransduction pathway involving receptor polarization, endocytosis, and proteolytic activation in response to fluid shear stress.

The paper develops synthetic CIC-family fusion oncoproteins to study their distinct transcriptional effects in cancer.

The paper compares monomeric StayGold variants using protein nanocages in living cells, finding mStayGold is 3-fold brighter and more photostable than EGFP and other variants.

This study shows DCX stabilizes microtubules in growth cones, enabling neuron morphogenesis in soft environments by resisting actomyosin contractile forces.

This study shows that somatic Alk1 mutation in arterial endothelial cells causes epistaxis and cerebral microhemorrhage in mice, suggesting a mechanism for HHT-associated bleeding.

This study shows that the C1 domain of CIC is required for full activity of the CIC::DUX4 fusion oncoprotein, highlighting the importance of breakpoint location in fusion function.