MicrobiologyScientific ReportsPeer-reviewed
Exploring mutational possibilities of KPC variants to reach high level resistance to cefiderocol
Sidonie Hanna, Kévin La, Yutaka Yoshii…·André Birgy
This study explores mutational possibilities in KPC variants to develop high-level cefiderocol resistance through random mutagenesis and selection, revealing that enzymatic and iron transport mutations interact in resistance mechanisms.