Kévin La

The paper quantifies how serotype replacement in Streptococcus pneumoniae is driven by shifts in serotypes within persistent lineages rather than lineage replacement, using genome-informed modeling and longitudinal data.

This study explores mutational possibilities in KPC variants to develop high-level cefiderocol resistance through random mutagenesis and selection, revealing that enzymatic and iron transport mutations interact in resistance mechanisms.

This study improves understanding of Mycobacterium tuberculosis lineage 5 diversity and phylogeography using new genomic data and a novel bioinformatics pipeline.