Longitudinal transcriptomic analysis of SIV-infected rhesus macaques reveals peripheral immune dynamics throughout untreated SIV infection and long-term antiretroviral therapy
Sarah Elizabeth Quinn, Micayla George, John D. Ventura, Emily J. Fray, Malika Aïd, Victoria E. K. Walker-Sperling, Janet D'Angelo Siliciano, Robert F. Siliciano, Son Nguyen, Dan H. Barouch, Alex K. Shalek
This study uses scRNA-seq to analyze immune changes in SIV-infected rhesus macaques over time, revealing immune shifts during infection and ART, and identifying transcriptional signatures linked to immune dysregulation and treatment outcomes.
bioRxiv · Aug 8, 2025 · PreprintImmunology