Comparison of germline and somatic structural variants in cancers reveal systematic differences in variant generating and selection processes
Wolu Chukwu, Siyun Lee, Alexander Crane, Shu Zhang, Sophie Webster, Ipsa Mittra, Marcin B. Imielinski, Rameen Beroukhim, Frank P. B. Dubois, Simona Dalin
The paper compares germline and somatic structural variants in cancer, identifying differences in their generating processes and selection, and develops a classifier to distinguish them in tumor samples without matched normals.
bioRxiv · Oct 9, 2023 · PreprintBioinformatics