Frank P. B. Dubois

Copy number signatures in targeted gene panels associate with patient outcomes in routine clinical data

The paper shows that copy number signatures from targeted gene panels are clinically relevant and associated with patient outcomes in ovarian, pancreatic, and colorectal cancers.

Extrachromosomal DNA micronucleation constrains tumour fitness andimproves patient survival

This study shows that ecDNA mis-segregation leads to micronuclei formation, reduced oncogene transcription, and improved patient survival in neuroblastoma.

Detecting significantly recurrent genomic connections from simple and complex rearrangements in the cancer genome

This paper introduces two methods to detect recurrent genomic rearrangements in cancer genomes and identifies 80 simple and 29 complex rearrangements across 2,500 cancers.

Comparison of germline and somatic structural variants in cancers reveal systematic differences in variant generating and selection processes

The paper compares germline and somatic structural variants in cancer, identifying differences in their generating processes and selection, and develops a classifier to distinguish them in tumor samples without matched normals.