Enzymatic modulation of the pulmonary glycocalyx alters susceptibility to Streptococcus pneumoniae
Cengiz Goekeri, K. Linke, Karen Hoffmann, Elena López-Rodríguez, Vladimir Gluhovic, Anne Voß, Sandra Kunder, Andreas Zappe, Sara Timm, Alina Nettesheim, Sebastian M.K. Schickinger, Christian Zobel, Kevin Pagel, Achim Dieter Gruber, Matthias Ochs, , Geraldine Nouailles
This study shows that enzymatic degradation of hyaluronan and heparan sulfate in the lung worsens Streptococcus pneumoniae infection by increasing inflammation, bacterial burden, and barrier disruption in mice and human models.
bioRxiv · Jan 3, 2024 · PreprintMolecular Biology