Kevin Pagel

This study shows glycosaminoglycans promote amyloid-β aggregation under acidic conditions through pH-dependent electrostatic interactions and multivalency.

This study shows that HMGB1's B-box domain forms self-associates that enhance interactions with heparin through charge redistribution and conformational changes.

This study examines how sialylated glycans and molecular size of bovine submaxillary mucins affect influenza virus inhibition.

This study shows that enzymatic degradation of hyaluronan and heparan sulfate in the lung worsens Streptococcus pneumoniae infection by increasing inflammation, bacterial burden, and barrier disruption in mice and human models.