Matthias Ochs

This study shows that high tidal volume ventilation acidifies alveolar lining fluid, increasing susceptibility to Pseudomonas pneumonia by reducing NHE1 expression.

This study identifies glycoRNA as a novel component of the alveolar epithelial glycocalyx and shows its role in barrier regulation and viral infection.

This study shows that enzymatic degradation of hyaluronan and heparan sulfate in the lung worsens Streptococcus pneumoniae infection by increasing inflammation, bacterial burden, and barrier disruption in mice and human models.