Benoît Vanhollebeke

This study shows that microtubule detyrosination promotes directional migration and matrix remodeling during endothelial sprouting by enhancing ECM degradation and force transmission.

This study identifies molecular mechanisms of flow-mediated vessel fusion in zebrafish models of Vein of Galen aneurysmal malformation and demonstrates pharmacological reversal of the malformation.

This study identifies Sorbs1's role in zebrafish lymphatic and venous vessel development, showing it regulates cytoskeleton dynamics and BMP signaling, distinct from Vegfc pathways.

This study shows engineered Wnt7a ligands improve blood brain barrier and neurobehavioral deficits in a SARS-CoV-2 infected mouse model.

The paper identifies a core angiogenic mechanism involving Vegfc/d and Vegfa that drives region-specific development of fenestrated capillaries in the brain.

This study identifies heme-deficient metabolism and impaired cellular differentiation as evolutionary trade-offs for human infectivity in Trypanosoma brucei gambiense due to HpHbR inactivation.

This study identifies a missense mutation in the furinb gene in zebrafish that causes hepatic cysts by disrupting ER homeostasis and mTOR signaling during liver development.

The paper provides guidelines and tools to optimize CRISPR/Cas9 genome targeting efficiency and specificity by considering target locus, guide RNA design, delivery methods, and off-target detection.