Michael F. Freeman

This paper identifies and characterizes the sinefungin biosynthetic gene cluster, revealing unconventional biocatalytic strategies involving a B12-dependent radical SAM enzyme and PEARLs for nucleoside modification.

The paper updates a genome mining tool to identify borosin precursor peptides and characterizes new biosynthetic features.

TaxiBGC improves BGC prediction in metagenomes by using taxonomy-guided methods, showing better performance than read-based approaches and linking BGCs to human diseases.