BiochemistryJournal of the American Chemical SocietyPeer-reviewed
Unconventional biocatalytic strategies orchestrate synthesis of the nucleoside analog sinefungin
Chi‐Fang Lee, Tianhui H. Zhou, Songyi Xue…·Michael F. Freeman
This paper identifies and characterizes the sinefungin biosynthetic gene cluster, revealing unconventional biocatalytic strategies involving a B12-dependent radical SAM enzyme and PEARLs for nucleoside modification.
DOI 10.1021/jacs.6c10565