Author

Gil Alterovitz

Brigham and Women's HospitalORCID 0000-0002-0495-7059Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Shaojun PeiiD· 3 shared Aadya GoeliD· 1 shared Alex Handler WagneriD· 1 shared Andrew D. YatesiD· 1 shared Brian WalshiD· 1 shared Daniel CameroniD· 1 shared David KredaiD· 1 shared Eric MoyeriD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioinformatics

Shaojun PeiORCID

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Author profile →

5 papers

Recent·Most cited

Multiscale Transcriptomic Architecture of the ALS Motor Cortex

Aadya Goel, Shaojun Pei, Gil Alterovitz

The paper identifies seven subtypes of ALS motor cortex with distinct molecular programs and shows they are organized by genetic and clinical factors rather than disease duration.

bioRxiv · Oct 30, 2026 · PreprintBioinformatics

SpaCoEx: Sparse Gene Selection for Spatially Varying Co-expression in Spatial Transcriptomics

Michale Jian, Shaojun Pei, Gil Alterovitz

SpaCoEx selects sparse genes for spatially varying co-expression in spatial transcriptomics, improving spatial coherence and annotation agreement in cancer datasets.

bioRxiv · Sep 14, 2026 · PreprintBioinformatics

A Unified Protein Embedding Model with Local and Global Structural Sensitivity

Jinghong Xu, Shaojun Pei, Gil Alterovitz

This paper introduces a protein embedding model that captures both global and local structural similarity, outperforming existing methods in structural comparison tasks.

Briefings in Bioinformatics · Dec 1, 2025Peer-reviewedBioinformatics

Unveiling the Biochemical Mechanisms of Aging and the Implications of Oxidative Stress on Cellular Senescence through Multi-Omics Analysis of Fibroblasts

Rema Mandal, Ning Xie, Gil Alterovitz

This study uses multi-omics analysis of human fibroblasts to show that mitochondrial dysfunction and epigenetic changes drive aging, with specific treatments affecting cellular lifespan and metabolic balance.

bioRxiv · May 17, 2025 · PreprintGenomics

The GA4GH Variation Representation Specification (VRS): a Computational Framework for the Precise Representation and Federated Identification of Molecular Variation

Alex Handler Wagner, Lawrence J. Babb, Gil Alterovitz, Michael Baudis, Matthew Brush, Daniel Cameron, Melissa Cline, Malachi Griffith, Obi L. Griffith, Sarah E Hunt, David Kreda, Jennifer Lee, Stephanie Li, Javier Lopez, Eric Moyer, , Reece K. Hart

The paper introduces the GA4GH Variation Representation Specification (VRS), a framework for precise and federated representation of molecular variation, with a reference implementation and community resources available online.

Cell Genomics · Nov 1, 2021Peer-reviewedBioinformatics