Unveiling the Biochemical Mechanisms of Aging and the Implications of Oxidative Stress on Cellular Senescence through Multi-Omics Analysis of Fibroblasts
Rema Mandal, Ning Xie, Gil Alterovitz
This study uses multi-omics analysis of human fibroblasts to show that mitochondrial dysfunction and epigenetic changes drive aging, with specific treatments affecting cellular lifespan and metabolic balance.
bioRxiv · May 17, 2025 · PreprintGenomics