Guangpu Shi

Akkermansia expansion reduces short-chain fatty acid-producing Firmicutes in human-flora uveitis mice, raising Th1 responses and disease; a Verrucomicrobia/Firmicutes ratio is elevated in uveitis, MS and Crohn's patients.

IAN is an R package that integrates and interprets omics data using a multi-agent AI system with LLMs, demonstrating its ability to avoid hallucination and support biological discovery.

SCassist uses large language models to guide and enhance single-cell RNA sequencing analysis by providing recommendations and interpretations throughout the workflow.

This study produces the first high-quality chromosome-scale genome assembly of the B10.RIII mouse strain, which is highly susceptible to autoimmune diseases.

The paper reanalyzes a scRNA-seq dataset to identify Muller cell subgroups and their functional dynamics in retinal inflammation, revealing their role in modulating Th1 cell activity.