Author

Jaanam Gopalakrishnan

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:software / tool· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:large language model· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Guangpu ShiiD· 2 shared Rachel R CaspiiD· 2 shared Vijayaraj NagarajaniD· 2 shared Calla Gentilucci· 1 shared Cheng‐Rong YuiD· 1 shared Chunhong LiuiD· 1 shared David A. MurphyiD· 1 shared Jennifer A. KellyiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Guangpu ShiORCID

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Author profile →

3 papers

Recent·Most cited

IAN: An Intelligent System for Omics Data Analysis and Discovery

Vijayaraj Nagarajan, Reiko Horai, Guangpu Shi, Cheng‐Rong Yu, Jaanam Gopalakrishnan, Manoj Kumar Yadav, Michael H. Liew, Calla Gentilucci, Rachel R Caspi

IAN is an R package that integrates and interprets omics data using a multi-agent AI system with LLMs, demonstrating its ability to avoid hallucination and support biological discovery.

Cell Reports Methods · Jun 16, 2026Peer-reviewedBioinformatics

SCassist: An AI Based Workflow Assistant for Single-Cell Analysis

Vijayaraj Nagarajan, Guangpu Shi, Samyuktha Arunkumar, Chunhong Liu, Jaanam Gopalakrishnan, Pulak Ranjan Nath, Jun‐Ho Jang, Rachel R Caspi

SCassist uses large language models to guide and enhance single-cell RNA sequencing analysis by providing recommendations and interpretations throughout the workflow.

Bioinformatics · Jul 12, 2025Peer-reviewedBioinformatics

Massively Parallel Reporter Assay Confirms Regulatory Potential of hQTLs and Reveals Important Variants in Lupus and Other Autoimmune Diseases

Yao Fu, Jennifer A. Kelly, Jaanam Gopalakrishnan, Richard C. Pelikan, Kandice L. Tessneer, Satish Pasula, Kiely M. Grundahl, David A. Murphy, Patrick M. Gaffney

The paper uses a massively parallel reporter assay to identify variants influencing gene expression in lupus and autoimmune diseases, finding hQTLs are more functional than eQTLs and identifying 31 putative causal variants.

Human Genetics and Genomics Advances · Feb 23, 2024Peer-reviewedGenomics