Sergiu Paşca

The paper shows that inherited and somatic mitochondrial DNA heteroplasmies contribute to hematological malignancies and high-risk clonal hematopoiesis, with most disease-related burden acquired during life.

This study identifies CCRL2 as a driver of IFN-γ signaling in TP53-mutated AML with erythroid differentiation, linking it to disease progression and poor outcomes.

This study shows that mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms when added to existing CHIP-based models.