Yun Soo Hong

Deleterious mitochondrial heteroplasmy drives high-risk clonal hematopoiesis and hematological malignancy

The paper shows that inherited and somatic mitochondrial DNA heteroplasmies contribute to hematological malignancies and high-risk clonal hematopoiesis, with most disease-related burden acquired during life.

Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants

This study shows that deleterious mitochondrial DNA mutations increase over time and are associated with higher mortality risk, suggesting positive selection rather than genetic drift.

Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms

This study shows that mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms when added to existing CHIP-based models.

Deleterious heteroplasmic mitochondrial mutations increase risk of overall and cancer-specific mortality

This study identifies that heteroplasmic mitochondrial mutations increase mortality risk and are linked to cancer incidence and outcomes, particularly leukemia.

Mitochondrial DNA Copy Number and Incident Atrial Fibrillation

This study investigates the association between mitochondrial DNA copy number and risk of atrial fibrillation in three cohorts, finding an inverse relationship after adjustment for traditional risk factors.