Wen Shi

The paper shows that inherited and somatic mitochondrial DNA heteroplasmies contribute to hematological malignancies and high-risk clonal hematopoiesis, with most disease-related burden acquired during life.

This study shows that deleterious mitochondrial DNA mutations increase over time and are associated with higher mortality risk, suggesting positive selection rather than genetic drift.

This study shows that mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms when added to existing CHIP-based models.

This paper develops a method to jointly model gene-environment correlations and interactions using polygenic risk scores in case-control studies, showing improved performance over standard approaches in detecting breast cancer risk interactions.

This study identifies that heteroplasmic mitochondrial mutations increase mortality risk and are linked to cancer incidence and outcomes, particularly leukemia.

This study identifies 100 loci associated with mitochondrial DNA copy number and finds causal links between mitochondrial function and mortality.