A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding
Sandra Hess, Marta Campos Alonso, Michael J. D. Brand, Susan Lauw, Urs Lindenmann, Katharina Göbel, Paul P. Geurink, Günter Fritz, Rainer Riedl, Klaus‐Peter Knobeloch
The paper develops a NanoBRET assay to monitor USP18 interactions and identifies a small molecule inhibitor of USP18/ISG15 binding.
bioRxiv · Mar 30, 2025 · PreprintMolecular Biology