Paul P. Geurink

This study shows that isopeptidase and esterase activities of deubiquitinases have distinct catalytic requirements, with cysteine not strictly needed for esterase activity.

This study identifies a novel E3 ligase secreted by Pseudomonas aeruginosa that regulates virulence through ubiquitin modification.

This study investigates the role of USP8 in B-cell development and multiple myeloma, showing its impact on proteostasis and identifying potential therapeutic strategies.

This study identifies eight small-molecule enhancers of circadian rhythm amplitude in both central and peripheral clocks through a drug repurposing screen and ex vivo validation.

This study identifies USP24 as a novel ISG15 cross-reactive deubiquitinase that de-ISGylates MOV10 to negatively regulate IFN-I production.

This paper develops a competitive binding HTS assay to identify small molecule ligands for bacterial PreQ1 riboswitches, discovering 4 hits with activity against multiple riboswitches and one showing translation inhibition.

The paper develops a mass spectrometry-based assay to screen E2/E3 ligase pairs for their ability to form ubiquitin chains and analyze chain types.

This paper introduces Huib32, a selective USP32 inhibitor, and two activity-based probes that modulate endosomal processes and provide tools for studying USP32 in cancer and neurodegenerative diseases.

The paper develops a high-throughput synthesis-to-screening method to identify selective USP18 inhibitors from a cyanimide library.

The paper develops a NanoBRET assay to monitor USP18 interactions and identifies a small molecule inhibitor of USP18/ISG15 binding.