Leukemia escapes immunity by imposing a Type-1 regulatory program on neoantigen-specific CD4+ T cells.
Hrishi Venkatesh, Enoc Granados Centeno, Qianyun Luo…·Sean I. Tracy
This paper shows leukemia induces neoantigen-specific CD4+ T cells to become regulatory (Tr1) cells, which suppress cytotoxic T cells and promote relapse, and repolarizing these cells to Th1 states eradicates residual disease.