Peter A. Crawford

This study investigates the role of neuronal and hepatic ketone metabolism in cognitive enhancement from exercise and time-restricted feeding in mice, finding neuronal utilization is essential while hepatic production is contributory.

This study shows that (R,S)-1,3-butanediol improves memory in female tauopathy mice on chow but not on high-fat diets or after long-term use, highlighting sex and diet-dependent cognitive benefits.

This study shows that liver-specific HMGCS2 knockout reduces exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

This study shows that dietary sulfur amino acid restriction improves glucose homeostasis by enhancing hepatic de novo serine synthesis through PSAT1, but not lipid metabolism.

The paper shows that residual HIV production in lymph nodes of ART-suppressed individuals drives pyroptosis and is counter-regulated by GLP-1 upregulation in the ileum.

This study shows dietary restriction enhances CD8+ T cell ketolysis, improving mitochondrial function and anti-tumor immunity by reducing exhaustion.

This study identifies APOE4-dependent metabolic changes in brain cells, showing increased glycolysis and mitochondrial dysfunction in neurons and astrocytes.

The paper shows that ketone bodies support thermogenic adaptation in BAT during fasting by promoting lipid remodeling and thermogenesis.

This study shows that PDK1 regulates triacylglycerol turnover in cardiomyocytes under nutrient deprivation, independent of its role in glucose metabolism.

This study uses multiomic analysis to investigate metabolic interactions between colorectal cancer cells and hepatocytes in liver metastasis, revealing metabolic shifts and potential therapeutic targets.

The paper shows ketogenesis supports PUFA homeostasis in hepatocytes by enabling FA elongation, and its disruption leads to lipid imbalances similar to MASLD.

The paper shows aerobic capacity and exercise enhance bile acid metabolism, which is critical for reducing hepatic steatosis in mice.

This study shows that a ketogenic diet reduces pain in mice through ketone oxidation and activation of ATP-gated potassium channels.

This study shows that ketone metabolism is essential for the development and function of the somatosensory nervous system, with loss of ketolysis causing myelination deficits and proprioceptive impairments.

This study shows that mitochondrial citrate metabolism and efflux regulate trophoblast differentiation through effects on histone acetylation and gene expression.