Heme drives cardiac endothelial senescence in sepsis via STING activation
Tingting Li, Peilin Zhu, Jialing Wang, Tao Zhang, Joseph Adams, Fei Tu, Chloe G. Garbe, Xiaojin Zhang, Li Liu, Krishna Singh, David L. Williams, Chuanfu Li, Xiaohui Wang
This study identifies heme as a driver of cardiac endothelial senescence in sepsis through STING activation, showing that targeting heme clearance improves cardiac function.
Cell Death and Disease · Dec 18, 2025Peer-reviewedCell Biology