Author

David L. Williams

East Tennessee State UniversityORCID 0000-0002-4586-9290Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

David L. Williams1 paper · Rush University Medical Center

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Abhinav DiwaniD· 1 shared Anant JaiswaliD· 1 shared Attila D KovácsiD· 1 shared Chloe G. GarbeiD· 1 shared Chuanfu LiiD· 1 shared Douglas L. ManniD· 1 shared Fei TuiD· 1 shared Jialing WangiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperImmunology

Abhinav DiwanORCID

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Author profile →

3 papers

Recent·Most cited

Heme drives cardiac endothelial senescence in sepsis via STING activation

Tingting Li, Peilin Zhu, Jialing Wang, Tao Zhang, Joseph Adams, Fei Tu, Chloe G. Garbe, Xiaojin Zhang, Li Liu, Krishna Singh, David L. Williams, Chuanfu Li, Xiaohui Wang

This study identifies heme as a driver of cardiac endothelial senescence in sepsis through STING activation, showing that targeting heme clearance improves cardiac function.

Cell Death and Disease · Dec 18, 2025Peer-reviewedCell Biology

Lipopolysaccharide Induces Trained Innate Immune Tolerance in the Heart Through Interferon Signaling in a Model of Stress-Induced Cardiomyopathy

Kenji Rowel Q. Lim, Junedh Amrute, Attila D Kovács, Abhinav Diwan, David L. Williams, Douglas L. Mann

This study shows that LPS pretreatment protects hearts from ISO-induced injury through TLR4-mediated interferon signaling, involving both cell-autonomous and non-cell-autonomous mechanisms.

Cardiovascular Research · Sep 9, 2025Peer-reviewedImmunology

Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms

Anant Jaiswal, László Halász, David L. Williams, Timothy F. Osborne

This study shows Setdb2 regulates trained immunity in macrophages through two distinct epigenetic mechanisms, differing between pathogenic and sterile inflammatory triggers.

bioRxiv · Mar 18, 2025 · PreprintImmunology