RTN4IP1 is essential for the final stages of mitochondrial complex I assembly and coenzyme Q biosynthesis
Monika Oláhová, Rachel M. Guerra, Jack J. Collier, Juliana Heidler, Kyle Thompson, Chelsea R. White, Paulina Castañeda-Támez, Alfredo Cabrera‐Orefice, Robert Neil Lightowlers, Zofia M. A. Chrzanowska-Lightowlers, Alexander S. Galkin, Ilka Wittig, David J. Pagliarini, Robert William Taylor
This study shows RTN4IP1 is critical for mitochondrial complex I assembly and coenzyme Q biosynthesis, with mutations causing defects in both processes in patient cells.
The EMBO Journal · Aug 26, 2025Peer-reviewedCell Biology