Author

Zofia M. Chrzanowska‐Lightowlers

Newcastle UniversityORCID 0000-0002-0045-3152Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Monika OláhováiD· 2 shared Robert Neil LightowlersiD· 2 shared Robert William TayloriD· 2 shared Adam R. CreighiD· 1 shared Alberto SanziD· 1 shared Alexander S. GalkiniD· 1 shared Alfredo Cabrera‐OreficeiD· 1 shared Ana AndjelkovićiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Monika OláhováORCID

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3 papers

Recent·Most cited

Pathogenic PTCD1 variants cause mitochondrial protein aggregation and cardiomyopathy

Ana Andjelković, Noah Wetterich, Michael Bull, Arthur Fox, Filippo Scialò, Daniella Helena Hock, Benjamin B. A. Raymond, Langping He, Nichola Zoe Lax, Matthias Trost, Zofia M. Chrzanowska‐Lightowlers, Alberto Sanz, David A. Stroud, Jarno Mäkelä, Robert William Taylor, , Monika Oláhová

This study identifies pathogenic PTCD1 variants causing mitochondrial protein aggregation and cardiomyopathy by disrupting mitoribosome biogenesis and proteostasis.

bioRxiv · Jun 11, 2026 · PreprintCell Biology

RTN4IP1 is essential for the final stages of mitochondrial complex I assembly and coenzyme Q biosynthesis

Monika Oláhová, Rachel M. Guerra, Jack J. Collier, Juliana Heidler, Kyle Thompson, Chelsea R. White, Paulina Castañeda-Támez, Alfredo Cabrera‐Orefice, Robert Neil Lightowlers, Zofia M. A. Chrzanowska-Lightowlers, Alexander S. Galkin, Ilka Wittig, David J. Pagliarini, Robert William Taylor

This study shows RTN4IP1 is critical for mitochondrial complex I assembly and coenzyme Q biosynthesis, with mutations causing defects in both processes in patient cells.

The EMBO Journal · Aug 26, 2025Peer-reviewedCell Biology

Engineering bacterial protein polymers to support human pluripotent stem cell growth and differentiation in culture.

Adam R. Creigh, Helen Waller, Jeremy H. Lakey, Zofia M. Chrzanowska‐Lightowlers, Robert Neil Lightowlers, Daniel T. Peters

This study develops Caf1 protein variants that support iPSC growth and differentiation as effectively as GelTrex, offering a defined and cost-effective alternative to animal-derived substrates.

bioRxiv · Apr 29, 2024 · PreprintBioengineering