Cancer BiologyNaturePeer-reviewed
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Genetic elements promote retention of extrachromosomal DNA in cancer cells
Venkat Sankar, King L. Hung, Aditi Gnanasekar…·Howard Y. Chang
A genome-wide plasmid screen, Retain-seq, identifies thousands of CpG-rich promoter-like human elements that tether episomes to mitotic chromosomes, shape ecDNA structure, and lose function when methylated.