Author

Britney Jiayu He

Scripps Research InstituteORCID 0000-0001-8989-1521Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Howard Y. ChangiD· 2 shared Katerina KraftiD· 2 shared King L. HungiD· 2 shared Matthew G. JonesiD· 2 shared Paul S. MischeliD· 2 shared Quanming ShiiD· 2 shared Aarohi Bhargava-ShahiD· 1 shared Aditi GnanasekariD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Howard Y. ChangORCID

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3 papers

Recent·Most cited

Cell BiologyNature Cell BiologyPeer-reviewedJun 11, 2026

TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells

Yiran Wang, Jindayi Liang, Kimberly Lange…·Danfeng Cai

The paper shows TEAD1 forms transcriptionally inactive condensates in cancer cell pericentromeric heterochromatin, acting as storage sites and influencing YAP/TEAD target gene expression.

4 citationstop 2%

humanChIP-seq

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Cancer BiologyNaturePeer-reviewedNov 19, 2025

✦ In-depth digest

Genetic elements promote retention of extrachromosomal DNA in cancer cells

Venkat Sankar, King L. Hung, Aditi Gnanasekar…·Howard Y. Chang

A genome-wide plasmid screen, Retain-seq, identifies thousands of CpG-rich promoter-like human elements that tether episomes to mitotic chromosomes, shape ecDNA structure, and lose function when methylated.

25 citationstop 1%

humanHi-C

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GeneticsNature Cell BiologyPeer-reviewedOct 21, 2025

Enhancer activation from transposable elements in extrachromosomal DNA

Katerina Kraft, Sedona E. Murphy, Matthew G. Jones…·Howard Y. Chang

The paper identifies enhancer-like elements on ecDNA in colorectal cancer that are derived from transposable elements and are functionally active in cancer cell fitness.

20 citationstop 1%

humanexperimental assay

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