Author

Sylvie Jaillard

InsermORCID 0000-0002-0593-0261Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:benchmark study· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Christèle DubourgiD· 2 shared Alexandra AfenjariD· 1 shared Alexandre ReymondiD· 1 shared Alice Masurel· 1 shared Alistair T. PagnamentaiD· 1 shared Amandine Etcheverry· 1 shared Andrew O.M. WilkieiD· 1 shared Arthur SorliniD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenetics

Christèle DubourgORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Gene editing is suitable to treat GM1 Gangliosidosis: a proof-of-concept study

Delphine Leclerc, Louise Goujon, Sylvie Jaillard, Bénédicte Nouyou, Laurence Cluzeau, Léna Damaj, Christèle Dubourg, Amandine Etcheverry, Thierry Levade, Roseline Froissart, Stéphane Dréano, X. Guillory, Leif Axel Eriksson, Erika Launay, F. Mouriaux, , David Gilot

This study shows that adenine base editors can correct 41% of GLB1 pathogenic SNVs in patient-derived fibroblasts, restoring β-gal activity without significant off-target effects.

bioRxiv · Apr 17, 2022 · PreprintGenetics

The enrichment of breakpoints in late-replicating chromatin provides novel insights into chromoanagenesis mechanisms

Nicolas Chatron, Giuliana Giannuzzi, Pierre‐Antoine Rollat‐Farnier, Flavie Diguet, Eleonora Porcu, Tony Yammine, Kévin Uguen, Zohra-Lydia Bellil, Julia Lauer Zillhardt, Arthur Sorlin, Flavie Ader, Alexandra Afenjar, Joris Andrieux, Claire Bardel, Eduardo Calpena, , Caroline Schluth‐Bolard

The paper analyzes chromoanagenesis breakpoints in constitutional and cancer cases, finding enrichment in late-replicating chromatin and suggesting similar mechanisms for both.

bioRxiv · Jul 17, 2020 · PreprintGenomics