Author

David Gilot

InsermORCID 0000-0002-2646-671XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Marc AubryiD· 2 shared Amandine Etcheverry· 1 shared Anaïs M. Quéméner· 1 shared Anaïs Paris· 1 shared Antti MatvereiD· 1 shared Aris GaciiD· 1 shared Arthur Gautron· 1 shared Aurélie GoyenvalleiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Marc AubryORCID

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3 papers

Recent·Most cited

Molecular BiologyMolecular Therapy — Nucleic AcidsPeer-reviewedMay 24, 2025

A Genome-wide CRISPR screen unveils the endosomal maturation protein WDR91 as a promoter of productive ASO activity in melanoma

Grégory Menchon, Aris Gaci, Antti Matvere…·Rémy Pedeux

The paper identifies WDR91 as a promoter of ASO activity in melanoma through a CRISPR screen, highlighting its role in endosomal maturation and ASO efficacy.

7 citations

humanexperimental assay

𝕏 PostBluesky

GeneticsbioRxivPreprintApr 17, 2022

Gene editing is suitable to treat GM1 Gangliosidosis: a proof-of-concept study

Delphine Leclerc, Louise Goujon, Sylvie Jaillard…·David Gilot

This study shows that adenine base editors can correct 41% of GLB1 pathogenic SNVs in patient-derived fibroblasts, restoring β-gal activity without significant off-target effects.

2 citations

humanexperimental assay

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Cancer BiologybioRxivPreprintJul 8, 2020

Gain-of-function CRISPR screens identify tumor-promoting genes conferring melanoma cell plasticity and therapy-resistance

Arthur Gautron, Laura Bachelot, Anaïs M. Quéméner…·David Gilot

This study identifies tumor-promoting genes via CRISPR screens that confer melanoma cell plasticity and therapy resistance, showing SMAD3's role in BRAFi-resistance and potential as a therapeutic target.

DOI 10.1101/2020.07.08.193102

humangenetic perturbation / CRISPR

𝕏 PostBluesky