PhysiologybioRxivPreprint
Hepatocyte FGF21 is not required for fasting-induced metabolic responses but guides protein appetite after energy depletion
Justine Bruse, Clothilde Marbach, Arnaud Polizzi…·Anne Fougerat
DOI 10.1101/2025.10.22.683899
Author
Thierry Levade
Centre Hospitalier Universitaire de ToulouseORCID 0000-0003-3793-2584Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2022-2025 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- PhysiologyiSciencePeer-reviewed
Effect of thermoneutral housing on MASLD severity, hepatic gene expression, and BAT activation during β3-adrenergic stimulation in mice
Céline Marie Pauline Martin, Arnaud Polizzi, Valérie Alquier‐Bacquie…·Nicolas Loiseau
This study shows thermoneutral housing worsens MASLD in mice by increasing obesity, inflammation, fibrosis, and impairing BAT activation during β3-adrenergic stimulation.
8 citationstop 4% - BiochemistryJournal of Clinical InvestigationPeer-reviewed
Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins
TianMeng Xu, Rachel Heon‐Roberts, Travis Moore…·Alexey V. Pshezhetsky
This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.
- Cell BiologyPLoS BiologyPeer-reviewed
p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD
Marion Régnier, Arnaud Polizzi, Tiffany Fougeray…·Hervé Guillou
This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.
4 citations - GeneticsbioRxivPreprint
Gene editing is suitable to treat GM1 Gangliosidosis: a proof-of-concept study
Delphine Leclerc, Louise Goujon, Sylvie Jaillard…·David Gilot
This study shows that adenine base editors can correct 41% of GLB1 pathogenic SNVs in patient-derived fibroblasts, restoring β-gal activity without significant off-target effects.
2 citations