Timothy J. Hines

This study shows LIS1 depletion in adult mice causes axonal degeneration in projection neurons, suggesting LIS1's role in maintaining axon integrity in mature neurons.

The paper describes a mouse model with a Tuba4a mutation causing spastic ataxia and myopathy, showing disease progression and specific neurological and muscular defects.

The paper tests SIPA1L2 as a modifier of CMT1A using mouse models and identifies some genetic interactions but finds a small overall effect on neuropathy.

This paper shows that Lis1 is essential for axonal transport in adult mice, with loss of Lis1 causing severe neurological symptoms and death.