BiochemistrybioRxivPreprint
Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification
Martín Hugo, Lissy Z. F. Gross, Andresa Messias…·Hamed Alborzinia
This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.
DOI 10.1101/2025.11.13.687868