Author

Martín Hugo

Universitat Autònoma de BarcelonaORCID 0000-0003-3430-6457Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexander AdibekianiD· 1 shared Andreas TrumppiD· 1 shared Andresa MessiasiD· 1 shared Antonio Martı́nez-RuiziD· 1 shared Ashok Kumar JayaveluiD· 1 shared Biplab GhoshiD· 1 shared Carsten BerndtiD· 1 shared Daniel AbeggiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Alexander AdibekianORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 15, 2026

A covalent irreversible inhibitor binds in two mutually exclusive conformations to the active-site cysteine residue of human aldehyde dehydrogenase 1A3

Daniela Covaleda, David Vizarraga, Tulsi Upadhyay…·Jaume Farrés

This paper identifies a covalent irreversible inhibitor, Z34, that binds to ALDH1A3 in two distinct conformations at the active-site cysteine, showing promise for anticancer drug development.

DOI 10.64898/2026.07.14.738401

humanprotein structure

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BiochemistrybioRxivPreprintNov 13, 2025

Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification

Martín Hugo, Lissy Z. F. Gross, Andresa Messias…·Hamed Alborzinia

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

DOI 10.1101/2025.11.13.687868

humanexperimental assay

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