Engineering temporal alignment of mRNA delivery enables functional rescue across genetic infertility models
Qiang Jiang, Kai Su, Guangnan Li, Huali Luo, Hao Wang, Jingwen Luo, Ya-Ni Zhong, Qiaodan Li, Zhihui Zhang, Haifeng Zhang, Wenlin Li, Banghua He, Chenyu Pei, Qin Li, Liang Xu, , Xin Zhiguo Li
This study identifies temporal mismatch between mRNA delivery and spermatogenesis as a barrier to functional rescue, showing that sustained expression aligned with developmental timing enables recovery in genetic infertility models.
bioRxiv · Nov 13, 2025 · PreprintBioengineering