Xin Zhiguo Li

This study shows that type 2 diabetes increases susceptibility to lead toxicity, leading to organ damage and intergenerational health risks.

This study identifies temporal mismatch between mRNA delivery and spermatogenesis as a barrier to functional rescue, showing that sustained expression aligned with developmental timing enables recovery in genetic infertility models.

The paper identifies DNA damage hypersensitivity in chicken PGCs as a barrier to CRISPR-Cas9 editing and demonstrates shRNA as a viable alternative for functional screening.

The paper reanalyzes sperm chromatin structure in mice, finding that prior studies were contaminated by cell-free chromatin, and identifies open loci associated with early development.

The paper shows that ribosomes guide piRNA production from mRNAs in 3UTRs after translating upstream long ORFs, revealing a conserved mechanism for piRNA biogenesis.

The paper shows that RNF8 is not required for histone-to-protamine exchange in spermiogenesis, contradicting a previous study.

The paper develops a cost-effective rRNA depletion method for avian species, enabling RNA-seq and ribosome profiling by using custom-designed oligos, and applies it to chickens and mice.

The paper uses single-molecule long-read sequencing to identify conserved long RNA profiles in sperm and reveals a post-transcriptional selection mechanism shaping these profiles in mice and humans.