Oleg V. Sobolev

The paper introduces a mosaic bulk-solvent model that improves the fit between crystallographic models and data, enhancing density map quality and solving previously inaccessible problems.

This paper improves macromolecular structure refinement using Phenix and OPLS3e for better structure and ligand quality in X-ray and cryo-EM data.

This paper introduces a quantum-based refinement method for cryo-EM maps to improve atomic model accuracy at low resolutions using quantum-chemical restraints.

The paper introduces new computational tools for validating cryo-EM maps and atomic models, including methods for resolution estimation, map sharpening, and map analysis.

The paper describes real-space refinement in Phenix for improving cryo-EM models using additional restraints and shows significant model improvement.