Novel insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis.
Yasuaki Uehara, Yusuke Tanaka, Shuyang Zhao, Nikolaos M. Nikolaidis, Lori B. Pitstick, Huixing Wu, Jane J. Yu, Erik Y. Zhang, Yoshihiro Hasegawa, John G. Noel, Jason C. Gardner, Elizabeth J. Kopras, Wendy D. Haffey, Kenneth D. Greis, Jinbang Guo, , Francis X. McCormack
This study identifies Npt2b and pulmonary osteoclast-like cells as key regulators of phosphate homeostasis and microlith clearance in PAM.
Nature Communications · Mar 2, 2023Peer-reviewedMolecular Biology