Jane J. Yu

Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics

This study identifies two distinct LAM subtypes and their microenvironmental interactions using multi-omics and spatial transcriptomics, revealing key regulatory networks and potential therapeutic targets.

Extracellular vesicles regulate metastable phenotypes of lymphangioleiomyomatosis cells via shuttling ATP synthesis to pseudopodia and activation of integrin adhesion complexes.

This study shows that extracellular vesicles from LAM cells promote metastasis by delivering ATP to pseudopodia and activating integrin adhesion complexes.

STAT1 Promotes PD-L1 Activation and Tumor Growth in Lymphangioleiomyomatosis

This study identifies STAT1 as a driver of LAM cell survival and tumor growth by promoting PD-L1 expression and immune evasion in TSC2-deficient models.

Screening activity of brain cancer-derived factors on primary human brain pericytes

The paper investigates how brain cancer-derived factors affect primary human brain pericytes, identifying specific signaling pathways and functional changes.

Human iPSC-derived brain pericytes exhibit differences in inflammatory activation compared to primary human brain pericytes

This study compares the inflammatory responses of iPSC-derived brain pericytes to primary human brain pericytes, finding differences in NFκB and STAT1 activation and cytokine secretion.

Novel insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis.

This study identifies Npt2b and pulmonary osteoclast-like cells as key regulators of phosphate homeostasis and microlith clearance in PAM.

Connectivity analysis of single cell RNA-sequencing derived transcriptional signature of lymphangioleiomyomatosis

The paper develops methods to construct disease transcriptional signatures and perform connectivity analysis using scRNA-seq data, identifying mTORC1 and other inhibitors as potential therapies for LAM.