Erik Y. Zhang

This study identifies two distinct LAM subtypes and their microenvironmental interactions using multi-omics and spatial transcriptomics, revealing key regulatory networks and potential therapeutic targets.

This study identifies STAT1 as a driver of LAM cell survival and tumor growth by promoting PD-L1 expression and immune evasion in TSC2-deficient models.

This study identifies Npt2b and pulmonary osteoclast-like cells as key regulators of phosphate homeostasis and microlith clearance in PAM.

The paper develops methods to construct disease transcriptional signatures and perform connectivity analysis using scRNA-seq data, identifying mTORC1 and other inhibitors as potential therapies for LAM.