Ilayda Ilerten

EcoNet improves immunotherapy response prediction by modeling tumor microenvironment signaling networks, outperforming existing methods in AUC and stratifying ccRCC patients by clinical outcome.

The paper integrates mouse lymph node tumor data with human melanoma tumors to identify transcriptional programs and ecotypes associated with metastasis.

The paper updates the PRECOG resource by adding pediatric and immunotherapy datasets, enabling analysis of gene expression associations with clinical outcomes using statistical models and deconvolution.