Cancer BiologybioRxivPreprint
Molecular Profiling and High-Content Drug Screening of Metastatic Colorectal Cancer Organoids Reveal Evolutionary Mechanisms of Pan-KRAS Inhibitor Resistance
Gizem Damla Yalçın, Kubra Celikbas Yilmaz, Raffaella Klima…·Ahmet Acar
This study uses patient-derived organoids and single-cell RNA sequencing to investigate resistance mechanisms to pan-KRAS inhibitors in metastatic colorectal cancer.